The two primary regulatory drivers for hazardous waste at USG institutions are the Resource Conservation and Recovery Act (RCRA) and the Georgia Environmental Protection Division (EPD) Rules for Hazardous Waste Management.

RCRA is a federal law that gave the U.S. Environmental Protection Agency the authority to implement regulations to control hazardous waste from the point of generation ("cradle") to its ultimate disposal point ("grave"). The waste generator is one of the principal parties responsible for meeting these regulations.

The Georgia EPD Rules for Hazardous Waste Management essentially adopt the federal RCRA regulations and are promulgated for the purpose of protecting and enhancing the quality of Georgia's environment and protecting the public health, safety and well being of its citizens.